Should You Get Another Covid Booster?

The FDA has authorized additional shots for older Americans and those with certain immune deficiencies. Here’s what scientists know about who needs the doses, and when.

ImagePreparing a Covid shot in a vaccination clinic at Meritus Medical Center in Maryland last month.
Credit …Kenny Holston for The New York Times

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Aiming to protect Americans who are most vulnerable to the coronavirus, the Food and Drug Administration on Tuesday authorized a second booster dose of Covid vaccine for all adults 50 and older. The agency’s decision comes as the highly contagious Omicron subvariant BA.2 pummels Europe and threatens to do the same in the United States.

But the scientific evidence for fourth dose is incomplete, at best, and researchers do not agree on whether the shots are needed. Here are some factors to consider when making your decision.

Two weeks ago, Pfizer asked the FDA to authorize a second booster shot of its vaccine – that is, a fourth dose – for people aged 65 and older. Two days later, Moderna followed suit, but with a broader request to authorize the second booster for all adults over 18.

Even before these requests, the leaders of these companies made the rounds on television shows arguing for another round of boosters for everyone – but without much evidence to back up their claims.

That did not deter the FDA The agency said on Tuesday that adults aged 50 and older could opt for a second booster shot of the vaccines made by Pfizer-BioNTech or Moderna, to be given at least four months after the first booster of any authorized or approved Covid vaccine.

Will the announcement make any difference in the torpid vaccination rates in the country, especially with cases still on a steady decline? Fewer than half of adults in the United States chose to get a booster shot even when the virus was ravaging the country, noted Dr. Saad Omer, director of the Yale Institute for Global Health.

“Our first booster coverage is very, very, very low compared to where we needed to be,” Dr. Omer said.

Instead of doubling down on a flawed approach, federal officials should take advantage of the lull in the pandemic to explore the best immunization strategies, he said.

“Any career public health person looking back and looking at the current coverage of the first booster would say, we need to have a sober assessment of what we need to do differently,” he said.

Receiving a fourth dose at a retirement community in Etanya, Israel.
Credit …Ammar Awad / Reuters

Many scientists are dubious about today’s decision.

The FDA’s authorization allows anyone over 50 to receive a second booster. But experts pointed out that the limited research so far supports a fourth shot only for those older than 65 or who have underlying conditions that put them at high risk.

The most compelling data comes from an Israeli study that found that adults older than 60 who got a fourth dose were 78 percent less likely to die of Covid than those who got only three shots. The study was posted online last week and has not yet been reviewed for publication in a scientific journal.

“The Israeli study, in terms of mortality rate, is decisive,” said Dr. Robert Wachter, chair of the Department of Medicine at the University of California, San Francisco.

But that study, while it offers the only evidence, is deeply flawed. The participants all volunteered to get a fourth shot – and are likely to be people who are naturally careful about their health, said Dr. Paul Offit, director of the Vaccine Education Center at Children’s Hospital of Philadelphia and an adviser to the FDA

“Who makes the choice to get a fourth dose? Someone who is attentive to their health, who’s more likely to exercise, is less likely to smoke, is more likely to wear a mask, ”Dr. Offit said.

These other factors may make the booster shot look more effective than it actually is. In fact, other data from Israel suggest that a second booster has only marginal benefits in healthy young people.

Given four months after the third dose, a fourth dose restored the level of antibodies to the same peak seen after the first booster, but no more than that. And this rise is likely to be fleeting, just as it was after the third dose.

“It’ll be short-lived, so I think the timing is going to be key here,” said Marion Pepper, an immunologist at the University of Washington. “If it’s not going to create a long-term, better quality immune response, then you question the value a little bit.”

Dozens of studies have now shown that most people are already well protected from severe illness. Even confronted with Omicron, a variant that can slip through immune defenses and infect people, two or three doses of the Pfizer-BioNTech or Moderna vaccines proved powerful enough to prevent severe illness in nearly everyone, according to a recent CDC study.

Most vaccinated people who became severely ill or died were older or had health conditions that compromised their immune response, the study found.

Probably only people who are immunocompromised or older than 65, according to the limited evidence available.

“If you’re more than five or six months out from your last booster, and you’re at high to very high risk,” the obvious choice is to get the shot, said Dr. Wachter.

“As a healthy 64-year-old man whose third shot was seven months ago, I will get one this week if I can,” he added.

Other experts were more circumspect about Americans rushing to get a second booster.

“I’m a firm believer in vaccines. I like the idea of ​​physicians and immunocompromised and high-risk patients having options, ”said John Wherry, director of the Institute of Immunology at the University of Pennsylvania.

But he balked at a blanket recommendation: “It’s hard for me to advocate making a decision about an intervention like this in the complete absence of data.”

Still, Dr. Wachter said he would recommend the booster to anyone who qualifies. The virus may only be thrumming along at a low volume right now, but it has not gone away. Americans who do not get boosters may be leaving themselves or others around them vulnerable to infection, he warned.

Recent studies have suggested that Covid may damage the heart or brain. Although vaccination significantly reduces the risk of long-term effects, the studies “are all lining up in a direction that says you do not want to have this infection if you can avoid it, even if you’re 100 percent confident you ‘ re not going to die, ”Dr. Wachter said.

If the goal is to maintain protection against infection, Americans may need boosters every few months. Several experts believe that is an impractical and unrealistic approach.

“That’s not a public health strategy, it’s not a reasonable strategy,” Dr. Offit said. “It also assumes no consequence to boosting.”

Nobody knows – yet. But it’s not unreasonable to think that it will help at least a little, at least in the short term.

Last fall, the Biden administration recommended booster shots for most Americans, in part to curtail spread of the virus. But the Israeli study in young people found that the fourth dose did not offer a strong bulwark against infection with Omicron.

The Pfizer-BioNTech vaccine had an efficacy of 30 percent at preventing infections with the variant, and the Moderna vaccine just 11 percent.

Still, reduced infections – to any degree – should mean lower odds that a boosted person will pass on the virus.

“There may be a short period of time – you know, one to three months – where you are getting increased protection from infection to some degree,” Dr. Wherry said. “That will of course then reduce transmission.”

A vaccination clinic in Hagerstown, Md., Last month.
Credit …Kenny Holston for The New York Times

The protection against infection from booster doses wanes quickly, in just a couple of months, so a booster shot now will not offer much defense in August or even July.

It takes the immune system about a week to rev up after the shot. From that peak, antibodies taper down over the next two to three months. So if you qualify for a booster, you may want to have the maximum protection right before your trip – or before the next surge.

“The one thing that matters is where we are in this whole pandemic,” Dr. Pepper said. “I would be watching what the variants are doing.”

Late last year, when the Omicron variant was ubiquitous, getting a booster made sense simply to prevent infections.

Dr. Wherry, who is 50, said he opted for a third dose even though he was not worried about becoming sick because getting infected would have been “extremely inconvenient” for his work and for his two children in high school.

“Right now as a healthy 50-year-old, I do not see any need for a fourth dose,” he said. But he might revisit that choice if the case numbers tick up again.

Maybe. The vaccines are overwhelmingly safe, so getting an extra dose is not dangerous. But there still may be disadvantages.

For example, each dose may induce side effects like fever, headache, fatigue and joint aches – “which, when you get older, are not always trivial,” Dr. Offit noted.

Repeated boosting also offers diminishing results. Dr. Pepper’s team has evidence suggesting that a fourth exposure to the virus – whether through infection or the vaccine – will not make immunity any stronger than it is after the third.

There is also some worry that repeatedly boosting with the original version of the vaccine will make the body less responsive to future versions. “When you’re boosting with the same strain versus different strains, you’re not getting the bang for the buck,” Dr. Omer said.

And there is some evidence that spacing vaccine doses farther apart, perhaps once a year, may produce a stronger, more long-lasting immune response. If that’s true, it would argue against frequent boosters.

Probably not for a while, all the experts said in interviews.

“You can conceptually think about an infection like a booster,” Dr. Wachter said. “Folks who did have an infection in the last three months are likely to be protected if they got a second booster.”

Dr. Pepper’s team found that in people who had been infected and then vaccinated, even the first booster shot did not offer much of an advantage.

“You sort of plateau at some sort of ceiling of immunity with three exposures to the spike protein, whether it’s through infection and vaccine or just vaccine alone,” Dr. Pepper said.

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